Docking Studies and Anti-inflammatory Activity of ÃŽÂ²-Hydroxy-ÃŽÂ²-arylpropanoic Acids

Docking Studies and Anti-inflammatory Activity of ÃŽÂ²-Hydroxy-ÃŽÂ²-arylpropanoic Acids

The article describes a two-step synthesis of diastereomeric 3-hydroxy-2-methyl-3-(4-biphenylyl)butanoic acids. In the first step an intermediate ÃŽÂ±-bromo propanoicacid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatskyreaction in presence of Zn in tetrahydrofuran (...

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Bibliographic Details
Main Authors:	Ivan O. Juranic, Sote M. Vladimirov, Bojan D. Markovic, Zorica D. Juranic, Silva Lj. Dobric, Sanda P. Dilber
Format:	Article
Language:	English
Published:	MDPI AG 2008-03-01
Series:	Molecules
Subjects:	ÃŽÂ²-Hydroxy-ÃŽÂ²-arylalkanoic acids Reformatsky reaction anti-inflammatory activity molecular docking simulations COX-2 selective inhibitor
Online Access:	http://www.mdpi.com/1420-3049/13/3/603/

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