Activation of the Cholinergic Anti-inflammatory Pathway Attenuated Angiotension II-Dependent Hypertension and Renal Injury

Activation of the Cholinergic Anti-inflammatory Pathway Attenuated Angiotension II-Dependent Hypertension and Renal Injury

Background: Angiotensin II (AngII) induces renal fibrosis, characterized by fibroblast proliferation, inflammatory cell infiltration and excessive extracellular matrix deposition, all of which was relevant closely to hypertension. The vagus nerve-related cholinergic anti-inflammatory pathway (CAP) m...

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Bibliographic Details
Main Authors: Shu-jie Wu, Zhe-wei Shi, Xue Wang, Fang-fang Ren, Zuo-yi Xie, Li Lei, Peng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
cholinergic anti-inflammatory pathway
autonomic control
AngII-induced hypertension
renal inflammation and fibrosis
GTS-21 dihydrochloride
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.593682/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.593682/full

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