Activation of the Cholinergic Anti-inflammatory Pathway Attenuated Angiotension II-Dependent Hypertension and Renal Injury

Activation of the Cholinergic Anti-inflammatory Pathway Attenuated Angiotension II-Dependent Hypertension and Renal Injury

Background: Angiotensin II (AngII) induces renal fibrosis, characterized by fibroblast proliferation, inflammatory cell infiltration and excessive extracellular matrix deposition, all of which was relevant closely to hypertension. The vagus nerve-related cholinergic anti-inflammatory pathway (CAP) m...

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Bibliographic Details
Main Authors:	Shu-jie Wu, Zhe-wei Shi, Xue Wang, Fang-fang Ren, Zuo-yi Xie, Li Lei, Peng Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Pharmacology
Subjects:	cholinergic anti-inflammatory pathway autonomic control AngII-induced hypertension renal inflammation and fibrosis GTS-21 dihydrochloride
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.593682/full

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