Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

Abstract Background The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases is overexpressed and correlates with poor prognosis and decreased survival in many cancers. The receptor family has been therapeutically targeted, yet tyrosine kinase inhibitors (TKIs) do no...

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Bibliographic Details
Main Authors: Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta, Joyce Schroeder
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Translational Medicine
Subjects:
EGFR
HER
Juxtamembrane domain
EJ1
Peptide stapling
Inflammatory breast cancer
Online Access:http://link.springer.com/article/10.1186/s12967-019-1939-7

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http://link.springer.com/article/10.1186/s12967-019-1939-7

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