A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts

A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts

Base excision repair (BER) is the predominant pathway for the removal of most forms of hydrolytic, oxidative, and alkylative DNA lesions. The precise functioning of BER is achieved via the regulation of each step by regulatory/accessory proteins, with the most important of them being poly(ADP-ribose...

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Bibliographic Details
Main Authors: Svetlana N. Khodyreva, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Alina S. Kochetkova, Alexandra A. Yamskikh, Ekaterina A. Maltseva, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Olga I. Lavrik
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
base excision repair enzymatic activity
CRISPR/Cas9
mRNA
poly(ADP-ribose) polymerase 1
poly(ADP-ribosyl)ation
Online Access:https://www.mdpi.com/2073-4409/13/4/302

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https://www.mdpi.com/2073-4409/13/4/302

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