Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause a debilitating disease that is primarily characterized by persistent joint pain. CHIKV has been emerging globally, while neither a vaccine nor antiviral medication is available. The anti-parasitic drug suramin was previous...

Full description

Bibliographic Details
Main Authors: Irina C. Albulescu, Leonie White-Scholten, Ali Tas, Tabitha E. Hoornweg, Salvatore Ferla, Kristina Kovacikova, Jolanda M. Smit, Andrea Brancale, Eric J. Snijder, Martijn J. van Hemert
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Viruses
Subjects:
chikv
alphavirus
antiviral
suramin
e2 envelope protein
attachment
fusion
drug repurposing
Online Access:https://www.mdpi.com/1999-4915/12/3/314

Internet

https://www.mdpi.com/1999-4915/12/3/314

Similar Items