Interaction of the pioneer transcription factor GATA3 with nucleosomes

GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their l...

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Bibliographic Details
Main Authors: Hiroki Tanaka, Yoshimasa Takizawa, Motoki Takaku, Daiki Kato, Yusuke Kumagawa, Sara A. Grimm, Paul A. Wade, Hitoshi Kurumizaka
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17959-y