Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Abstract Background Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor...

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Bibliographic Details
Main Authors: Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Genome Medicine
Subjects:
Hepatocellular carcinoma
Spatial transcriptomics
Therapeutic resistance
Neoadjuvant therapy
Immunotherapy
Tumor recurrence
Online Access:https://doi.org/10.1186/s13073-023-01218-y

Internet

https://doi.org/10.1186/s13073-023-01218-y

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