Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK

Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK

BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-Tr...

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Bibliographische Detailangaben
Hauptverfasser: Debabrata Panja, Justin W. Kenney, Laura D’Andrea, Francesca Zalfa, Anni Vedeler, Karin Wibrand, Rikiro Fukunaga, Claudia Bagni, Christopher G. Proud, Clive R. Bramham
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2014-11-01
Schriftenreihe:Cell Reports
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2211124714008705

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http://www.sciencedirect.com/science/article/pii/S2211124714008705

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