Butyrate and Class I Histone Deacetylase Inhibitors Promote Differentiation of Neonatal Porcine Islet Cells into Beta Cells

Butyrate and Class I Histone Deacetylase Inhibitors Promote Differentiation of Neonatal Porcine Islet Cells into Beta Cells

Neonatal porcine islets-like clusters (NPICCs) are a promising source for cell therapy of type 1 diabetes. Freshly isolated NPICCs are composed of progenitor cells and endocrine cells, which undergo a maturation process lasting several weeks until the normal beta cell function has developed. Here, w...

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Bibliographic Details
Main Authors: Yichen Zhang, Yutian Lei, Mohsen Honarpisheh, Elisabeth Kemter, Eckhard Wolf, Jochen Seissler
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
islet development
short chain fatty acids
butyrate
HDAC inhibitor
porcine islets
NPICCs
Online Access:https://www.mdpi.com/2073-4409/10/11/3249

Internet

https://www.mdpi.com/2073-4409/10/11/3249

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