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Efficacy of sofosbuvir as treatment for yellow fever: protocol for a randomised controlled trial in Brazil (SOFFA study)

Efficacy of sofosbuvir as treatment for yellow fever: protocol for a randomised controlled trial in Brazil (SOFFA study)

Introduction An ongoing outbreak of yellow fever (YF) has been reported in Brazil with 1261 confirmed cases and 409 deaths since July 2017. To date, there is no specific treatment available for YF. Recently published papers describing in vitro and animal models suggest a potential effect of antivira...

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Main Authors: Claudia Figueiredo-Mello, Luciana Vilas Boas Casadio, Vivian Iida Avelino-Silva, Ho Yeh-Li, Jaques Sztajnbok, Daniel Joelsons, Marilia Bordignon Antonio, João Renato Rebello Pinho, Fernanda de Mello Malta, Michele Soares Gomes-Gouvêa, Ana Paula Moreira Salles, Aline Pivetta Corá, Carlos Henrique Valente Moreira, Ana Freitas Ribeiro, Ana Catharina de Seixas Santos Nastri, Ceila Maria Sant'Ana Malaque, Ralcyon Francis Azevedo Teixeira, Luciana Marques Sansão Borges, Mario Peribañez Gonzalez, Luiz Carlos Pereira Junior, Tâmara Newman Lobato Souza, Alice Tung Wan Song, Luiz Augusto Carneiro D'Albuquerque, Edson Abdala, Wellington Andraus, Rodrigo Bronze de Martino, Liliana Ducatti, Guilherme Marques Andrade, Luiz Marcelo Sá Malbouisson, Izabel Marcilio de Souza, Flair José Carrilho, Ester Cerdeira Sabino, Anna S Levin
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/9/11/e027207.full
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https://bmjopen.bmj.com/content/9/11/e027207.full

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