Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.

Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for soluble proteins. An important example comprises the membrane proteins that bind amyloid β oligomers (AβOs). AβOs are neurotoxic ligands thoug...

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Bibliographic Details
Main Authors: Kyle C Wilcox, Matthew R Marunde, Aditi Das, Pauline T Velasco, Benjamin D Kuhns, Michael T Marty, Haoming Jiang, Chi-Hao Luan, Stephen G Sligar, William L Klein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4415972?pdf=render

Internet

http://europepmc.org/articles/PMC4415972?pdf=render

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