The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation

The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation

Successfully completing the S phase of each cell cycle ensures genome integrity. Impediment of DNA replication can lead to DNA damage and genomic disorders. In this study, we show a novel function for NDE1, whose mutations cause brain developmental disorders, in safeguarding the genome through S pha...

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Bibliographic Details
Main Authors: Shauna L Houlihan, Yuanyi Feng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
neurogenesis
DNA replication
DNA damage response
cerebral cortex
cohesin
heterochromatin
Online Access:https://elifesciences.org/articles/03297

Internet

https://elifesciences.org/articles/03297

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