LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy

LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy

Abstract In hepatocellular carcinoma (HCC), immunotherapy is vital for advanced-stage patients. However, diverse individual responses and tumor heterogeneity have resulted in heterogenous treatment outcomes. Our mechanistic investigations identified LAPTM4B as a crucial gene regulated by ETV1 (a tra...

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Bibliographic Details
Main Authors: Haojun Wang, Quanwei Zhou, Ding Fang Xie, Qingguo Xu, Tongwang Yang, Wei Wang
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06542-8

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https://doi.org/10.1038/s41419-024-06542-8

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