Heparanase-1: From Cancer Biology to a Future Antiviral Target

Heparan sulfate proteoglycans (HSPGs) are a major constituent of the extracellular matrix (ECM) and are found to be implicated in viral infections, where they play a role in both cell entry and release for many viruses. The enzyme heparanase-1 is the only known endo-beta-D-glucuronidase capable of d...

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Bibliographic Details
Main Authors: Nadjet Lebsir, Fabien Zoulim, Boyan Grigorov
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/15/1/237