Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines, the epidemic prevention and control are still challenging. Here, we employ a capsid and antigen structure engineering (CASE) strategy to manufacture an adeno-associated viral...

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Bibliographic Details
Main Authors: Fuhua Wu, Shuang Luo, Yongshun Zhang, Yangsen Ou, Hairui Wang, Zhaofei Guo, Chunting He, Shuting Bai, Penghui He, Min Jiang, Xiaoyan Chen, Guangsheng Du, Xun Sun
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
AAV vectors
Capsid engineering
Vaccine
Antigen structure design
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522003161

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http://www.sciencedirect.com/science/article/pii/S2211383522003161

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