Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors [v1; ref status: indexed, http://f1000r.es/z6]
One of the key phenomena in the adaptive immune response to infection and immunization is affinity maturation, during which antibody genes are mutated and selected, typically resulting in a substantial increase in binding affinity to the eliciting antigen. Advances in technology on several fronts ha...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2013-04-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/2-103/v1 |