Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension

Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension

Abstract Background The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B4 produced by homeostatic astrocytes directly acts on RGCs to increase survival and function in ocular hypertensio...

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Bibliographic Details
Main Authors: Shubham Maurya, Maggie Lin, Shruthi Karnam, Tanirika Singh, Matangi Kumar, Emily Ward, Jeremy Sivak, John G. Flanagan, Karsten Gronert
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Neurodegeneration
Subjects:
Glaucoma
Microglia reactivity
Lipoxins
Neurodegeneration
Retina
Optic nerve
Online Access:https://doi.org/10.1186/s13024-024-00775-z

Internet

https://doi.org/10.1186/s13024-024-00775-z

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