Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose

Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose

The results of structural studies on a series of halogen-substituted derivatives of 2-deoxy-D-glucose (2-DG) are reported. 2-DG is an inhibitor of glycolysis, a metabolic pathway crucial for cancer cell proliferation and viral replication in host cells, and interferes with D-glucose and D-mannose me...

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Bibliographic Details
Main Authors: Marcin Ziemniak, Anna Zawadzka-Kazimierczuk, Sylwia Pawlędzio, Maura Malinska, Maja Sołtyka, Damian Trzybiński, Wiktor Koźmiński, Stanisław Skora, Rafał Zieliński, Izabela Fokt, Waldemar Priebe, Krzysztof Woźniak, Beata Pająk
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
2-deoxy-D-glucose
2-DG analogues
hydrogen bonds
energy frameworks
Hirshfeld surface
NMR spectroscopy
Online Access:https://www.mdpi.com/1422-0067/22/7/3720

Internet

https://www.mdpi.com/1422-0067/22/7/3720

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