Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates.

Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates.

Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for potential mucosal immunomodulatory/inflammatory effects prior to further clinical development...

Full description

Bibliographic Details
Main Authors: Irina A Zalenskaya, Theresa Joseph, Jasmin Bavarva, Nazita Yousefieh, Suzanne S Jackson, Titilayo Fashemi, Hidemi S Yamamoto, Robert Settlage, Raina N Fichorova, Gustavo F Doncel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4459878?pdf=render

Internet

http://europepmc.org/articles/PMC4459878?pdf=render

Similar Items