Efficient Asymmetric Synthesis of (<i>S</i>)-<i>N</i>-Boc-3-hydroxypiperidine by Coexpressing Ketoreductase and Glucose Dehydrogenase

Efficient Asymmetric Synthesis of (<i>S</i>)-<i>N</i>-Boc-3-hydroxypiperidine by Coexpressing Ketoreductase and Glucose Dehydrogenase

(<i>S</i>)-<i>N</i>-Boc-3-hydroxypiperidine is an important intermediate of the anticancer drug ibrutinib and is mainly synthesized by the asymmetric reduction catalyzed by ketoreductase coupled with glucose dehydrogenase at present. In this study, the coexpression recombinan...

Full description

Bibliographic Details
Main Authors: Xinxing Gao, Qianqian Pei, Nianqing Zhu, Yi Mou, Jilei Liang, Xin Zhang, Shoushuai Feng
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Catalysts
Subjects:
(<i>S</i>)-<i>N</i>-Boc-3-hydroxypiperidine
coexpression strategy
activity ratio
ketoreductase
glucose dehydrogenase
Online Access:https://www.mdpi.com/2073-4344/12/3/304

Internet

https://www.mdpi.com/2073-4344/12/3/304

Similar Items