Comparative application of derivative spectrophotometric and HPLC techniques for the simultaneous determination of lamivudine and tenofovir disoproxil fumarate in fixed-dose combined drugs

Comparative application of derivative spectrophotometric and HPLC techniques for the simultaneous determination of lamivudine and tenofovir disoproxil fumarate in fixed-dose combined drugs

Abstract Background Lamivudine (LAM) and tenofovir disoproxil fumarate (TDF) are part of a fixed-dose combination (FDC) therapy recommended by WHO. Both drugs exhibit similar solubility in many solvent systems and tend to have overlapping spectra with maxima at 260 and 270 nm, respectively, in the U...

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Bibliographic Details
Main Authors: Edebi N. Vaikosen, Samuel J. Bunu, Jude N. Oraeluno, David Friday
Format: Article
Language:English
Published: SpringerOpen 2023-03-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Derivative spectrophotometry
Lamivudine
Tenofovir disoproxil fumarate
Third order
Comparative
Antiretrovirals
Online Access:https://doi.org/10.1186/s43094-023-00471-7

Internet

https://doi.org/10.1186/s43094-023-00471-7

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