A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome

A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome

LincRNAs enriched with high H3K4me1 and low H3K4me3 signals often have the enhancer-like features which are named as enhancer-associated lincRNAs (elincRNAs). ElincRNAs are considered to be indispensable for target gene transcription, which play important roles in development, signaling events, and...

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Bibliographic Details
Main Authors: Hui Liu, Tiantongfei Jiang, Shuyuan Wang, Xiang Chen, Xiaoyan Jin, Qi Wang, Xinhui Li, Jiaqi Yin, Tingting Shao, Yongsheng Li, Juan Xu, Qiong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
enhancer lincRNA
mouse embryonic stem cell
regularized regression model
epigenome
regulatome
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00427/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2019.00427/full

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