Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol‐requiring enzyme 1 alpha–X‐box binding protein 1 pathway by downregulating prostaglandin‐endoperoxide synthase 2

Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol‐requiring enzyme 1 alpha–X‐box binding protein 1 pathway by downregulating prostaglandin‐endoperoxide synthase 2

Abstract Introduction We tried to show the effect of sinomenine (SIN) in diabetic peripheral neuropathic pain (DPNP) and the related underlying mechanism. Methods Network pharmacological analysis and bioinformatics analysis were carried out for identification of the active ingredients of Sinomenium...

Full description

Bibliographic Details
Main Authors: Ji Chen, Peng Guo, Xinxin Liu, Huizhi Liao, Kemin Chen, Yuxia Wang, Jie Qin, Fengrui Yang
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Journal of Diabetes Investigation
Subjects:
Diabetic peripheral neuropathic pain
Sinomenine
Spinal cord microglia
Online Access:https://doi.org/10.1111/jdi.13938

Internet

https://doi.org/10.1111/jdi.13938

Similar Items