Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway

Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway

Abstract Background Ocular toxicity is a severe adverse effect that limits the chronic clinical use of the antiarrhythmic drug amiodarone. Here, we aimed to evaluate the cytoprotective effect of artemisinin and explore the potential signalling pathways in human retinal pigment epithelial (RPE) cell...

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Bibliographic Details
Main Authors: Chao Yang, Xia Zhao, Wenshu Zhou, Qin Li, Philip Lazarovici, Wenhua Zheng
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Journal of Translational Medicine
Subjects:
Artemisinin
Amiodarone
Human retinal pigment epithelial cells
Oxidative damage
AMPK
Ocular toxicity
Online Access:https://doi.org/10.1186/s12967-024-05593-x

Internet

https://doi.org/10.1186/s12967-024-05593-x

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