Differential modulation of cancer‐related genes by mitochondrial DNA haplogroups and the STING DNA sensing system

Differential modulation of cancer‐related genes by mitochondrial DNA haplogroups and the STING DNA sensing system

Abstract Activation of the Simulator of Interferon Genes (STING) system by mitochondrial (mt) DNA can upregulate type 1 interferon genes and enhance immune responses to combat bacterial and viral infections. In cancers, the tumor‐derived DNA activates STING leading to upregulation of IFN‐beta and in...

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Bibliographic Details
Main Authors: Kevin Schneider, Marilyn Chwa, Shari R. Atilano, Sonali Nashine, Nitin Udar, David S. Boyer, S. Michal Jazwinski, Michael V. Miceli, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:FASEB BioAdvances
Subjects:
cancer genes
mitochondrial DNA haplogroups
simulator of interferon genes (STING)
Online Access:https://doi.org/10.1096/fba.2019-00044

Internet

https://doi.org/10.1096/fba.2019-00044

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