Substrates and Loaded Iron Ions Relative Position Influence the Catalytic Characteristics of the Metalloenzymes Angelica archangelica Flavone Synthase I and Camellia sinensis Flavonol Synthase

Substrates and Loaded Iron Ions Relative Position Influence the Catalytic Characteristics of the Metalloenzymes Angelica archangelica Flavone Synthase I and Camellia sinensis Flavonol Synthase

Metalloenzymes are a class of enzymes that catalyze through the metal ions they load. Angelica archangelica flavone synthase I (AnFNS I) and Camellia sinensis flavonol synthase (CaFLS), both of which belong to metalloenzymes, have highly similar structures and metal catalytic cores. However, these t...

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Bibliographic Details
Main Authors: Zhen Wang, An Liu, Juan Liu, Xu Huang, Feiyao Xiao, Miaomiao Tian, Shenghua Ding, Si Qin, Yang Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
synthetic biology
2-oxoglutarate-dependent dioxygenase
fragment replacement
catalytic characteristics
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.902672/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.902672/full

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