Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Summary: Nucleosomes form heterogeneous groups in vivo, named clutches. Clutches are smaller and less dense in mouse embryonic stem cells (ESCs) compared to neural progenitor cells (NPCs). Using coarse-grained modeling of the pluripotency Pou5f1 gene, we show that the genome-wide clutch differences...

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Bibliographic Details
Main Authors: Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
chromatin structure
chromatin dynamics
single molecule tracking
mesoscale modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031603X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472031603X

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