Nordihydroguaiaretic Acid as a Novel Substrate and Inhibitor of Catechol <i>O-</i>Methyltransferase Modulates 4-Hydroxyestradiol-Induced Cyto- and Genotoxicity in MCF-7 Cells
Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in <i>Larrea</i> spp., which are widely used in South America to treat various diseases. In breast tissue, estradiol is metabolized to the catechol estrogens such as 4-hydroxyestradiol (4-OHE<sub>2</sub>), wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/7/2060 |