Low <i>JAK2</i> V617F Allele Burden in Ph-Negative Chronic Myeloproliferative Neoplasms Is Associated with Additional <i>CALR</i> or <i>MPL</i> Gene Mutations

Low <i>JAK2</i> V617F Allele Burden in Ph-Negative Chronic Myeloproliferative Neoplasms Is Associated with Additional <i>CALR</i> or <i>MPL</i> Gene Mutations

<i>JAK2</i> (Janus kinase 2) V617F, <i>CALR</i> (Calreticulin) exon 9, and <i>MPL</i> (receptor for thrombopoietin) exon 10 mutations are associated with the vast majority of Ph-negative chronic myeloproliferative neoplasms (MPNs). These mutations affect sequentia...

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Bibliographic Details
Main Authors: Tatiana V. Makarik, Adhamjon O. Abdullaev, Elena E. Nikulina, Svetlana A. Treglazova, Elena E. Stepanova, Irina N. Subortseva, Alla M. Kovrigina, Anait L. Melikyan, Sergei M. Kulikov, Andrey B. Sudarikov
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
myeloproliferative neoplasms
polycythemia vera
primary myelofibrosis
essential thrombocythemia
<i>JAK2</i> V617F
<i>MPL</i> W515L/K
Online Access:https://www.mdpi.com/2073-4425/12/4/559

Internet

https://www.mdpi.com/2073-4425/12/4/559

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