One-pot H/D exchange and low-coordinated iron electrocatalyzed deuteration of nitriles in D2O to α,β-deuterio aryl ethylamines

One-pot efficient synthesis of α,β-deuterio aryl ethylamines with high deuterium ratios using an easy-to-handle deuterated source under ambient conditions is desirable. Here the author report the electrosynthesis of α,β-deuterio aryl ethylamines from aryl acetonitriles using D2O.

Bibliographic Details
Main Authors: Rui Li, Yongmeng Wu, Changhong Wang, Meng He, Cuibo Liu, Bin Zhang
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33779-8