SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients

SARS-CoV-2 booster vaccination rescues attenuated IgG1 memory B cell response in primary antibody deficiency patients

BackgroundAlthough SARS-CoV-2 vaccines have proven effective in eliciting a protective immune response in healthy individuals, their ability to induce a durable immune response in immunocompromised individuals remains poorly understood. Primary antibody deficiency (PAD) syndromes are among the most...

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Bibliographic Details
Main Authors: Frank J. Lin, Alexa Michelle Altman Doss, Hannah G. Davis-Adams, Lucas J. Adams, Christopher H. Hanson, Laura A. VanBlargan, Chieh-Yu Liang, Rita E. Chen, Jennifer Marie Monroy, H. James Wedner, Anthony Kulczycki, Tarisa L. Mantia, Caitlin C. O’Shaughnessy, Saravanan Raju, Fang R. Zhao, Elise Rizzi, Christopher J. Rigell, Tiffany Biason Dy, Andrew L. Kau, Zhen Ren, Jackson S. Turner, Jane A. O’Halloran, Rachel M. Presti, Daved H. Fremont, Peggy L. Kendall, Ali H. Ellebedy, Philip A. Mudd, Michael S. Diamond, Ofer Zimmerman, Brian J. Laidlaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
immune memory
B cells
vaccination
primary antibody deficiency
common variable immunodeficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1033770/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1033770/full

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