Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties

Short‐Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties

Background The heart can metabolize the microbiota‐derived short‐chain fatty acid butyrate. Butyrate may have beneficial effects in heart failure, but the underlying mechanisms are unknown. We tested the hypothesis that butyrate elevates cardiac output by mechanisms involving direct stimulation of c...

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Bibliographic Details
Main Authors: Jacob Marthinsen Seefeldt, Casper Homilius, Jakob Hansen, Thomas Ravn Lassen, Nichlas Riise Jespersen, Rebekka Vibjerg Jensen, Ebbe Boedtkjer, Hans Erik Bøtker, Roni Nielsen
Format: Article
Language:English
Published: Wiley 2024-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
butyrate
contractile function
hemodynamics
metabolism
short‐chain fatty acids
vasorelaxation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.033744

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https://www.ahajournals.org/doi/10.1161/JAHA.123.033744

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