Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin

Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin

Abstract Background Acute kidney injury (AKI) is associated with a severe decline in kidney function caused by abnormalities within the podocytes' glomerular matrix. Recently, AKI has been linked to alterations in glycolysis and the activity of glycolytic enzymes, including pyruvate kinase M2 (...

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Bibliographic Details
Main Authors: Mohammed Alquraishi, Samah Chahed, Dina Alani, Dexter L. Puckett, Presley D. Dowker, Katelin Hubbard, Yi Zhao, Ji Yeon Kim, Laurentia Nodit, Huma Fatima, Dallas Donohoe, Brynn Voy, Winyoo Chowanadisai, Ahmed Bettaieb
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cell Communication and Signaling
Subjects:
Proteinuria
Pyruvate kinase M2
Podocyte
β-Catenin
Online Access:https://doi.org/10.1186/s12964-022-00884-6

Internet

https://doi.org/10.1186/s12964-022-00884-6

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