The Role and Mechanism of AMIGO3 in the Formation of Aberrant Neural Circuits After Status Convulsion in Immature Mice

The Role and Mechanism of AMIGO3 in the Formation of Aberrant Neural Circuits After Status Convulsion in Immature Mice

Leucine rich repeat and immunoglobulin-like domain-containing protein 1 (Lingo-1) has gained considerable interest as a potential therapy for demyelinating diseases since it inhibits axonal regeneration and myelin production. However, the results of clinical trials targeted at Lingo-1 have been unsa...

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Bibliographic Details
Main Authors: Xue Li, Yanan Pan, Jianxiong Gui, Zhixu Fang, Dishu Huang, Hanyu Luo, Li Cheng, Hengsheng Chen, Xiaojie Song, Li Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
status convulsion
aberrant neural circuit
immature mice
AMIGO3
ROCK/RhoA
PI3K/AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.748115/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.748115/full

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