TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner

TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner

TP53-induced glycolysis and apoptosis regulator (TIGAR) alleviates oxidative stress and protects against ischemic neuronal injury by shifting glucose metabolism into the pentose phosphate pathway (PPP). However, the brain alters glucose metabolism from PPP to glycolysis during prolonged ischemia. It...

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Bibliographic Details
Main Authors: Mengru Liu, Xinyu Zhou, Yue Li, Shijia Ma, Ling Pan, Xingxian Zhang, Wanqing Zheng, Zhanxun Wu, Ke Wang, Anil Ahsan, Jiaying Wu, Lei Jiang, Yangyang Lu, Weiwei Hu, Zhenghong Qin, Zhong Chen, Xiangnan Zhang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Redox Biology
Subjects:
TIGAR
Pentose phosphate pathway
Oxidative stress
Autophagy
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000957

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http://www.sciencedirect.com/science/article/pii/S2213231722000957

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