Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of cell entry. However, earlier steps of filo...

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Bibliographic Details
Main Authors: Francisco J. Zapatero-Belinchón, Erik Dietzel, Olga Dolnik, Katinka Döhner, Rui Costa, Barbara Hertel, Barbora Veselkova, Jared Kirui, Anneke Klintworth, Michael P. Manns, Stefan Pöhlmann, Thomas Pietschmann, Thomas Krey, Sandra Ciesek, Gisa Gerold, Beate Sodeik, Stephan Becker, Thomas von Hahn
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
Filovirus cell entry
attachment factors redundancy
SH-SY5Y cell line
host–pathogen interactions
Online Access:http://www.mdpi.com/1999-4915/11/3/275

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http://www.mdpi.com/1999-4915/11/3/275

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