Focal adhesion kinase inhibitors prevent osteoblast mineralization in part due to suppression of Akt-mediated stabilization of osterix

Focal adhesion kinase inhibitors prevent osteoblast mineralization in part due to suppression of Akt-mediated stabilization of osterix

Focal Adhesion Kinase (FAK) is an important regulator of tumor cell proliferation, survival and metastasis. As such it has become a therapeutic target of interest in cancer. Previous studies suggested that use of FAK tyrosine kinase inhibitors (TKIs) blocks osteolysis in in vivo models of bone metas...

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Bibliographic Details
Main Authors: Scott A. Gunn, Lauren M. Kreps, Huijun Zhao, Katelyn Landon, Jacob S. Ilacqua, Christina L. Addison
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Journal of Bone Oncology
Subjects:
Focal adhesion kinase
Osteoblast
Bone mineralization
Akt
FAK TKI
Alkaline phosphatase
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137422000227

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http://www.sciencedirect.com/science/article/pii/S2212137422000227

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