Molecular determinants of avoidance and inhibition of Pseudomonas aeruginosa MexB efflux pump

Molecular determinants of avoidance and inhibition of Pseudomonas aeruginosa MexB efflux pump

ABSTRACT Transporters of the resistance-nodulation-cell division (RND) superfamily of proteins are the dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of Pseudomonas aeruginosa is MexAB-OprM, in which the inner membrane transporter MexB is responsible for the rec...

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Bibliographic Details
Main Authors: Silvia Gervasoni, Jitender Mehla, Charles R. Bergen, Inga V. Leus, Enrico Margiotta, Giuliano Malloci, Andrea Bosin, Attilio V. Vargiu, Olga Lomovskaya, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
antibiotic resistance
multidrug efflux
machine learning
Pseudomonas aeruginosa
efflux pump inhibitors
Online Access:https://journals.asm.org/doi/10.1128/mbio.01403-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01403-23

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