A narrative review of estimands in drug development and regulatory evaluation: old wine in new barrels?

A narrative review of estimands in drug development and regulatory evaluation: old wine in new barrels?

Abstract Background An estimand defines the target of estimation for a clinical trial through specification of the treatment, target population, variable, population-level summary and of the strategies for intercurrent events. A carefully defined estimand aligns the clinical trial design and analysi...

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Bibliographic Details
Main Authors: M. Mitroiu, K. Oude Rengerink, S. Teerenstra, F. Pétavy, K. C. B. Roes
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Trials
Subjects:
Estimand
Intention-to-treat
Per protocol
Intercurrent event
Post-randomisation event
Study withdrawal
Online Access:http://link.springer.com/article/10.1186/s13063-020-04546-1

Internet

http://link.springer.com/article/10.1186/s13063-020-04546-1

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