Analysis pipeline for the epistasis search – statistical versus biological filtering

Analysis pipeline for the epistasis search – statistical versus biological filtering

Gene-gene interactions may contribute to the genetic variation underlying complex traits but have not always been taken fully into account. Statistical analyses that consider gene-gene interaction may increase the power of detecting associations, especially for low-marginal-effect markers, and may e...

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Bibliographic Details
Main Authors: Xiangqing eSun, Qing eLu, Shubhabrata eMukheerjee, Paul eCrane, Robert C Elston, Marylyn D Ritchie
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Genetics
Subjects:
genetic interaction
Epistasis
biological interaction
filtering pipeline
optimal search
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00106/full

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