Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes

Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes

Recombinant adeno-associated viruses (rAAVs) have emerged as one of the most promising gene therapy vectors that have been successfully used in pre-clinical models of heart disease. However, this has not translated well to humans due to species differences in rAAV transduction efficiency. As a resul...

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Bibliographic Details
Main Authors: Cindy Y. Kok, Shinya Tsurusaki, Marti Cabanes-Creus, Sindhu Igoor, Renuka Rao, Rhys Skelton, Sophia H.Y. Liao, Samantha L. Ginn, Maddison Knight, Suzanne Scott, Mario Mietzsch, Rebecca Fitzsimmons, Jessica Miller, Tamer M.A. Mohamed, Robert McKenna, James J.H. Chong, Adam P. Hill, James E. Hudson, Ian E. Alexander, Leszek Lisowski, Eddy Kizana
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
cardiotropic
hiPSC-CM
cardiac organoids
cardiac slices
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001249

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http://www.sciencedirect.com/science/article/pii/S2329050123001249

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