Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of heme has been linked to the activation of inflammatory systems, including the com...

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Bibliographic Details
Main Authors: Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Tom E. Mollnes, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
heme
complement
factor I
co-factor activity
hemopexin
hemolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.901876/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.901876/full

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