Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice

Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice

Abstract Background Perilipin 5 (Plin5) is well known to maintain the stability of intracellular lipid droplets (LDs) and regulate fatty acid metabolism in oxidative tissues. It is highly expressed in the heart, but its roles have yet to be fully elucidated. Methods Plin5-deficient mice and Plin5/le...

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Huvudupphovsmän: Lele Jian, Xing Gao, Chao Wang, Xiao Sun, Yuqiao Xu, Ruili Han, Yuying Wang, Shenhui Xu, Lan Ding, Jingjun Zhou, Yu Gu, Yuanlin Zhao, Ying Yang, Yuan Yuan, Jing Ye, Lijun Zhang
Materialtyp: Artikel
Språk:English
Publicerad: BMC 2023-09-01
Serie:Biology Direct
Ämnen:
Perilipin 5
Glucose utilization
Insulin resistance
Lactate
Myocardial hypertrophy
Länkar:https://doi.org/10.1186/s13062-023-00411-8

Internet

https://doi.org/10.1186/s13062-023-00411-8

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