Selenium-Substituted Monomethine Cyanine Dyes as Selective G-Quadruplex Spectroscopic Probes with Theranostic Potential

Selenium-Substituted Monomethine Cyanine Dyes as Selective G-Quadruplex Spectroscopic Probes with Theranostic Potential

The binding interactions of six ligands, neutral and monocationic asymmetric monomethine cyanine dyes comprising benzoselenazolyl moiety with duplex DNA and RNA and G-quadruplex structures were evaluated using fluorescence, UV/Vis (thermal melting) and circular dichroism (CD) spectroscopy. The main...

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Bibliographic Details
Main Authors: Ivana Fabijanić, Atanas Kurutos, Ana Tomašić Paić, Vanja Tadić, Fadhil S. Kamounah, Lucija Horvat, Anamaria Brozovic, Ivo Crnolatac, Marijana Radić Stojković
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomolecules
Subjects:
selenium-substituted cyanine dyes
DNA/RNA interaction
G-quadruplex selective recognition
Induced Circular Dichroism
mitochondrial accumulation
cell viability inhibitory effect
Online Access:https://www.mdpi.com/2218-273X/13/1/128

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https://www.mdpi.com/2218-273X/13/1/128

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