Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain

Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain

ABSTRACT The genomes of DNA tumor viruses regain nuclear localization after nuclear envelope breakdown during mitosis through the action of a viral protein with a chromatin-tethering domain (CTD). Here, we report that the human cytomegalovirus (HCMV) genome is maintained during mitosis by the CTD of...

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Bibliographic Details
Main Authors: Shelby M. Lyon, Kristen D. Yetming, Christina Paulus, Michael Nevels, Robert F. Kalejta
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
cancer
chromatin
herpes
latency
mitosis
transcription
Online Access:https://journals.asm.org/doi/10.1128/mBio.02410-20

Internet

https://journals.asm.org/doi/10.1128/mBio.02410-20

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