Multi-scale characterisation of homologous recombination deficiency in breast cancer

Multi-scale characterisation of homologous recombination deficiency in breast cancer

Abstract Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using ‘mutational signatures’. However, these patterns...

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Bibliographic Details
Main Authors: Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Medicine
Subjects:
Homologous recombination deficiency
Mutational signatures
PARP inhibition
Breast cancer
Transcriptional classifier
Single cell
Online Access:https://doi.org/10.1186/s13073-023-01239-7

Internet

https://doi.org/10.1186/s13073-023-01239-7

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