Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.

Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.

The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer MxA resistance. These resistance-associated amino ac...

Full description

Bibliographic Details
Main Authors: Benjamin Mänz, Dominik Dornfeld, Veronika Götz, Roland Zell, Petra Zimmermann, Otto Haller, Georg Kochs, Martin Schwemmle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3610643?pdf=render

Internet

http://europepmc.org/articles/PMC3610643?pdf=render

Similar Items