Cis-acting lnc-eRNA SEELA directly binds histone H4 to promote histone recognition and leukemia progression

Cis-acting lnc-eRNA SEELA directly binds histone H4 to promote histone recognition and leukemia progression

Abstract Background Long noncoding enhancer RNAs (lnc-eRNAs) are a subset of stable eRNAs identified from annotated lncRNAs. They might act as enhancer activity-related therapeutic targets in cancer. However, the underlying mechanism of epigenetic activation and their function in cancer initiation a...

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Bibliographic Details
Main Authors: Ke Fang, Wei Huang, Yu-Meng Sun, Tian-Qi Chen, Zhan-Cheng Zeng, Qian-Qian Yang, Qi Pan, Cai Han, Lin-Yu Sun, Xue-Qun Luo, Wen-Tao Wang, Yue-Qin Chen
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Genome Biology
Subjects:
Lnc-eRNA
SEELA
Histone H4
Histone recognition
Enhancer activity
Sphingolipid metabolism
Online Access:http://link.springer.com/article/10.1186/s13059-020-02186-x

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http://link.springer.com/article/10.1186/s13059-020-02186-x

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