Propofol Induces Cardioprotection Against Ischemia-Reperfusion Injury via Suppression of Transient Receptor Potential Vanilloid 4 Channel

Propofol Induces Cardioprotection Against Ischemia-Reperfusion Injury via Suppression of Transient Receptor Potential Vanilloid 4 Channel

Ca2+ entry via the transient receptor potential vanilloid 4 (TRPV4) channel contributes to Ca2+ overload and triggers many pathophysiological conditions, including myocardial ischemia/reperfusion (I/R) injury. Propofol, a widely used intravenous anesthetic, attenuates myocardial I/R injury. However,...

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Bibliographic Details
Main Authors: Binbin Wang, Qiongfeng Wu, Jie Liao, Shaoshao Zhang, Huixia Liu, Cui Yang, Qian Dong, Ning Zhao, Zhengrong Huang, Kefang Guo, Yimei Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
propofol
TRPV4
cardioprotection
ischemia-reperfusion injury
calcium
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01150/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01150/full

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